The Relationship between Left Ventricular Diastolic Function Parameters and Coronary Artery Disease Severity

Area of Science:

• Cardiology
• Echocardiography
• Cardiac Imaging

Background:

• The relationship between diastolic function parameters and coronary artery disease (CAD) severity remains debated.
• Left ventricular (LV) diastolic function assessment is crucial for understanding CAD.
• This study investigates the link between LV diastolic function and CAD severity.

Purpose of the Study:

• To determine the relationship between left ventricular diastolic function and the severity of coronary artery disease (CAD).
• To compare the efficacy of 2D strain echocardiography with conventional echocardiography in assessing CAD severity.

Main Methods:

• A cross-sectional study of 63 patients with suspected or confirmed ischemic heart disease (IHD).
• Coronary angiography was performed to assess CAD severity.
• Two-dimensional (2D) strain echocardiography was used to evaluate LV diastolic function parameters.

Main Results:

• Conventional echocardiography parameters (E/e', LAVI, TRV, MPI, dt) showed no significant correlation with CAD severity (SYNTAX score).
• Left atrial (LA) strain, global longitudinal strain (GLS), early diastolic strain rate, and systolic strain rate correlated significantly with CAD severity.
• GLS demonstrated the strongest correlation with CAD severity.

Conclusions:

• 2D strain echocardiography parameters, particularly GLS, are more closely related to CAD severity than conventional echocardiography.
• Diastolic strain rates show a weaker correlation with CAD severity compared to GLS.
• GLS is a valuable parameter for assessing the severity of coronary artery disease.