Related Experiment Video
Updated: May 31, 2025
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice
Published on: April 13, 2015
The Relationship between Left Ventricular Diastolic Function Parameters and Coronary Artery Disease Severity
Khadije Mohammadi1, Mohammad Masoomi1, Mahsa Akrami1
1Cardiovascular Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Insights
Global longitudinal strain (GLS) and diastolic strain rates correlate with coronary artery disease (CAD) severity, unlike conventional echocardiography parameters. GLS shows the strongest correlation with CAD severity.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Imaging
Background:
- The relationship between diastolic function parameters and coronary artery disease (CAD) severity remains debated.
- Left ventricular (LV) diastolic function assessment is crucial for understanding CAD.
- This study investigates the link between LV diastolic function and CAD severity.
Purpose of the Study:
- To determine the relationship between left ventricular diastolic function and the severity of coronary artery disease (CAD).
- To compare the efficacy of 2D strain echocardiography with conventional echocardiography in assessing CAD severity.
Main Methods:
- A cross-sectional study of 63 patients with suspected or confirmed ischemic heart disease (IHD).
- Coronary angiography was performed to assess CAD severity.
- Two-dimensional (2D) strain echocardiography was used to evaluate LV diastolic function parameters.
Main Results:
- Conventional echocardiography parameters (E/e', LAVI, TRV, MPI, dt) showed no significant correlation with CAD severity (SYNTAX score).
- Left atrial (LA) strain, global longitudinal strain (GLS), early diastolic strain rate, and systolic strain rate correlated significantly with CAD severity.
- GLS demonstrated the strongest correlation with CAD severity.
Conclusions:
- 2D strain echocardiography parameters, particularly GLS, are more closely related to CAD severity than conventional echocardiography.
- Diastolic strain rates show a weaker correlation with CAD severity compared to GLS.
- GLS is a valuable parameter for assessing the severity of coronary artery disease.
Background:
The relationship between diastolic function parameters and the severity of coronary artery disease (CAD) is controversial. This study aimed to determine the relationship between left ventricular diastolic function and the severity of CAD.
Methods:
This cross-sectional study included 63 patients with Ischemic heart disease (IHD) or those suspected of having IHD, who underwent angiography. The study was conducted in Shafa Hospital, Kerman, Iran, from 2021 to 2022. Two-dimensional (2D) strain echocardiography was used to assess left ventricular (LV) function parameters, followed by coronary angiography. Based on the severity of the disease, patients with significant CAD were placed in the case group, and patients with insignificant CAD were placed in the control group. The correlation between the CAD severity and the severity of LV diastolic dysfunction was computed. Descriptive tests, independent t tests, and Spearman correlation coefficients were used. P<0.05 was considered statistically significant.
Results:
The results indicated that there was no correlation between E/e' (P=0.103), left atrial volume index (LAVI) (P=0.168), tricuspid regurgitation velocity (TRV) (P=0.217), myocardial performance index (MPI) (P=0.106), E wave deceleration time (dt) (P=0.644), and late diastolic strain rate (P=0.502) with CAD severity based on SYNTAX score. However, there was a correlation between left atrial (LA) strain (P=0.017), global longitudinal strain (GLS) (P<0.001), early diastolic strain rate (P<0.001), and systolic strain rate (P=0.047) with SYNTAX score. Besides, there was a correlation between LA strain (P=0.017), GLS (P<0.001), early diastolic strain rate (P<0.001), and late diastolic strain rate (P=0.035) with numbers of epicardial coronary arteries with significant lesions.
Conclusion:
In contrast with 2D strain echocardiography, this study showed that conventional echocardiography parameters had no significant relationship with CAD severity. GLS had the strongest correlation with CAD severity, and diastolic strain rates had a weaker correlation with CAD severity.
More Related Videos
08:09Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
Published on: December 13, 2019
11:04Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
Published on: September 1, 2014
Related Concept Videos
01:26Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
01:17Pathophysiology of Heart Failure