Related Experiment Video

Updated: May 31, 2025

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

4.5K

Trends, Characteristics and Outcomes in Breast Cancer Survivors With STEMI

Jia Ee Chia1, Song Peng Ang2, Muhammed Haris Usman3

  • 1Department of Internal Medicine, Texas Tech University Health Science Center, El Paso, TX, USA.

Angiology
|January 22, 2025
PubMed

Insights

Breast cancer survivors hospitalized for ST-elevation myocardial infarction (STEMI) experienced lower in-hospital mortality and fewer complications. These findings suggest improved care may benefit this patient group.

Area of Science:

  • Cardiology
  • Oncology
  • Public Health

Background:

  • Breast cancer is the most common cancer in women, and survivors have an increased risk of cardiovascular disease.
  • Limited data exist on cardiac outcomes for breast cancer survivors experiencing ST-elevation myocardial infarction (STEMI).

Purpose of the Study:

  • To investigate in-hospital mortality and cardiac outcomes in breast cancer survivors hospitalized with STEMI.
  • To compare outcomes between breast cancer survivors and women without a history of breast cancer following STEMI.

Main Methods:

  • Retrospective cohort study using the National Inpatient Sample (NIS) database from 2016-2021.
  • Inclusion of adult women hospitalized with STEMI, categorized into breast cancer survivors and non-survivors.
  • Multivariable logistic regression analysis to adjust for confounding factors and assess primary outcome (in-hospital mortality) and secondary outcomes.

Main Results:

  • The study included 369,070 women (13,890 breast cancer survivors).
  • Breast cancer survivors were older and had more cardiovascular comorbidities.
  • Adjusted analysis revealed lower odds of in-hospital mortality (aOR 0.82), cardiogenic shock (aOR 0.88), and acute kidney injury (aOR 0.85) in breast cancer survivors.

Conclusions:

  • Breast cancer survivors hospitalized for STEMI demonstrated better in-hospital outcomes, including reduced mortality and complications.
  • These findings may indicate the positive impact of advancements in both oncology and cardiovascular care.
  • Further research is needed to confirm these hypothesis-generating results and explore underlying mechanisms.

Keywords:
ST-elevation myocardial infarction (STEMI)breast cancercardio-oncologycardiotoxicitycoronary artery diseasewomen’s health

More Related Videos

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease12:15

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Published on: February 8, 2022

2.5K
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

2.4K

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
327
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
95
Kaplan-Meier Approach01:24

Kaplan-Meier Approach

The Kaplan-Meier estimator is a non-parametric method used to estimate the survival function from time-to-event data. In medical research, it is frequently employed to measure the proportion of patients surviving for a certain period after treatment. This estimator is fundamental in analyzing time-to-event data, making it indispensable in clinical trials, epidemiological studies, and reliability engineering. By estimating survival probabilities, researchers can evaluate treatment effectiveness,...
83