Peptide Nanofibers and Skin Regeneration

Peptide nanofibers have been attractive targets for regenerative medicine applications due to their tailorability to be easily functionalized for specific bioactivity, biocompatibility, ease of synthesis, adjustability of their physicochemical characteristics, and lack of biological contamination. Research groups have investigated their use for the regeneration of various tissues, such as bone, cartilage, brain, peripheral nerves, cardiac tissue, vascular tissues, endocrine cells, muscles, etc., for the treatment of degenerative diseases or tissue loss due to accidents or aging. Wound healing and skin regeneration are among the most widely investigated research areas for peptide nanofibers as well. In this article, we reviewed the literature on the utilization of peptide nanofibers for various skin regeneration and dermal healing applications, aiming to give the readers a general view of how peptide nanofibers have been used for this purpose so far as well as provide new insight on which avenues more research is necessary to be able to apply these methods in clinics.