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Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

348
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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The Micturition Reflex01:26

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Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
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Disorders of the Urinary System01:20

Disorders of the Urinary System

229
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
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Drugs for Treatment of Diarrhea-Predominant IBS01:17

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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Related Experiment Video

Updated: May 31, 2025

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
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Purported Bladder Irritant Intake in Women With Urgency Urinary Incontinence.

Barbara Ha1, Lisa R Yanek2, Bryna J Harrington1

  • 1From the Division of Urogynecology and Reconstructive Pelvic Surgery, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD.

Urogynecology (Philadelphia, Pa.)
|January 22, 2025
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Summary

Urgency urinary incontinence in women is linked to consuming caffeinated, carbonated, citrus beverages, and high-acid foods. Further research is needed to confirm these dietary links for better clinical guidance.

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Area of Science:

  • Urology
  • Dietary Science
  • Epidemiology

Background:

  • Urinary incontinence is a common condition in women.
  • Dietary recommendations for managing urgency urinary incontinence lack strong evidence.
  • Identifying specific dietary triggers is crucial for patient management.

Purpose of the Study:

  • To investigate the association between consumption of specific bladder irritants and urgency urinary incontinence (UUI) in adult women.
  • To compare dietary habits of women with UUI to those without the condition.

Main Methods:

  • A case-control study utilizing data from the National Health and Nutrition Examination Survey (2007-2020).
  • Inclusion criteria: nonpregnant females aged 20 years and older.
  • Exposures: consumption of alcohol, spicy foods, chocolate, artificial sweeteners, caffeinated/carbonated/citrus beverages, and high-acid foods.

Main Results:

  • The study included 651 cases of UUI and 8,890 controls.
  • Women with UUI were more likely to consume caffeinated, carbonated, and citrus beverages (53.8% vs 47.1%) and high-acid foods (50.3% vs 44.3%).
  • Multivariable analysis showed increased odds of UUI associated with these beverages (OR 1.37) and high-acid foods (OR 1.29).

Conclusions:

  • Urgency urinary incontinence in adult women is associated with the consumption of caffeinated, carbonated, citrus beverages, and high-acid foods.
  • These findings suggest potential dietary modifications for managing UUI.
  • Further prospective studies are warranted to confirm these associations and inform clinical practice.