[Study of the antioxidative activity of anti-inflammatory agents]

Antioxidative activity of analginum, amidopyrine, butadion, acetylsalicilic acid, ascorbic and mephenamine acids, indometacin, bruphene, voltarene, delagil, prednisolone and hydrocortisone was studied. The antioxidative activity was estimated by means of inhibition of chemoluminescence in liver mitochondria and blood serum as well as by evaluation of malonic dialdehyde and diene conjugates content. Lipid peroxidation was shown to accelerate in inflammation as shown by accumulation of malonic dialdehyde and diene conjugates. The drugs studied inhibited lipid peroxidation in intact animals and in animals with experimental inflammation.