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Fixation and Sectioning01:03

Fixation and Sectioning

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Two basic types of preparation are used to visualize specimens with a light microscope: wet mounts and fixed specimens.
The simplest type of preparation is the wet mount, in which the specimen is placed in a drop of liquid on the slide. A liquid specimen can be directly deposited on the slide using a dropper. Solid specimens, such as skin scraping, can be placed on the slide before adding a drop of liquid to prepare the wet mount. Sometimes the liquid is simply water, but stains are often added...
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To be visualized by an electron microscope, either transmission or scanning, biological samples need to be fixed (stabilized) so the electron beam does not destroy them and dried thoroughly (desiccated/dehydrated) so the vacuum does not affect them. Fixation needs to be done as quickly as possible because the sample properties will start changing as soon as it is removed from its natural environment. For example, in a tissue sample, the oxygen levels begin decreasing, causing an altered...
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Sample Preparation for Analysis: Advanced Techniques

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Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
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Sample Handling01:02

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Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
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Preparing Adherent Cells for X-ray Fluorescence Imaging by Chemical Fixation
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Linking Research Data with Physically Preserved Research Materials in Chemistry.

Chia-Lin Lin1, Pei-Chi Huang1, Simone Gräßle1

  • 1Institute of Biological and Chemical Systems - Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology, Kaiserstraße 12, 76131, Karlsruhe, Germany.

Scientific Data
|January 22, 2025
PubMed
Summary

Publishing FAIR data is crucial for chemistry reproducibility. Integrating materials archives with data repositories enhances transparency and sustainability by linking physical samples to their research data.

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Area of Science:

  • Chemistry
  • Data Science
  • Materials Science

Background:

  • Scientific results in chemistry are typically materials and data.
  • FAIR data principles enhance transparency and reproducibility.
  • Preservation of physical materials is essential for sustainable chemistry.

Purpose of the Study:

  • To develop a comprehensive infrastructure for accessing chemical data and materials.
  • To integrate the Chemotion repository with a chemical compound archive.
  • To link physical samples with their associated FAIR research data.

Main Methods:

  • Combining the Chemotion repository with a materials archive.
  • Creating FAIR metadata for virtual sample representations.
  • Linking virtual samples to physical samples and research data.
  • Implementing measures for sample findability, accessibility, and reusability.

Main Results:

  • A unified infrastructure for accessing chemical data and materials.
  • Successful linking of virtual sample metadata to physical samples.
  • Established a connection between physical samples and FAIR research data.
  • Enhanced findability, accessibility, and reusability of physical chemical samples.

Conclusions:

  • Integrating data repositories with materials archives is key for sustainable chemistry.
  • FAIR metadata for virtual samples enables robust sample tracking and data linkage.
  • Comprehensive infrastructure improves transparency, reproducibility, and reusability in chemical research.