CD45-PET is a robust, non-invasive tool for imaging inflammation.

Area of Science:

• Medical Imaging
• Immunology
• Nuclear Medicine

Background:

• Imaging inflammation is crucial for diagnosing and treating diseases.
• Current positron emission tomography (PET) probes lack specificity and sensitivity for inflammation detection.

Purpose of the Study:

• To develop and evaluate CD45-PET imaging as a sensitive and specific tool for detecting and monitoring inflammation.

Main Methods:

• Developed CD45-PET imaging probes for preclinical and clinical use.
• Assessed probe sensitivity and specificity in preclinical models of inflammatory lung and bowel diseases.
• Compared CD45-PET with 18F-fluorodeoxyglucose PET for inflammation imaging.
• Validated a human CD45-PET probe in a humanized mouse model.

Main Results:

• CD45-PET imaging demonstrated exceptional sensitivity and clarity in detecting inflammation.
• CD45-PET signal intensity robustly correlated with disease severity in preclinical models.
• CD45-PET outperformed 18F-fluorodeoxyglucose PET in detecting inflammation.
• Longitudinal CD45-PET enabled precise monitoring of dynamic inflammatory changes.
• A human CD45-PET probe successfully detected human immune cells in vivo.

Conclusions:

• CD45-PET imaging offers a sensitive and specific method for assessing inflammation.
• This technique can guide diagnostic and therapeutic decisions for inflammatory diseases.
• CD45-PET provides precise, whole-body inflammation profiling for individual patients.