Optimized heparin adsorption using macroporous zeolites: A comprehensive study

Area of Science:

• Biomaterials Science
• Pharmaceutical Chemistry
• Adsorption Technology

Background:

• Heparin is a vital pharmaceutical ingredient extracted from porcine intestinal mucosa.
• Traditional extraction methods use commercial resins, prompting research into cost-effective alternatives.
• Zeolites, with their high surface area and porosity, are promising candidates for adsorbent applications.

Purpose of the Study:

• To evaluate the efficacy of two zeolites, CBV901 and CBV10A, for heparin recovery.
• To determine the adsorption capacity and efficiency of selected zeolites.
• To analyze the adsorption mechanism and optimize the recovery process.

Main Methods:

• Screening of CBV901 and CBV10A zeolites for heparin adsorption from porcine intestinal mucosa.
• Quantification of heparin adsorption efficiency and capacity.
• Kinetic and thermodynamic modeling to understand adsorption mechanisms.
• Investigation of adsorption time and sorbent reusability.

Main Results:

• CBV901 zeolite achieved 44% efficiency and 23.3 mg/g adsorption capacity for heparin.
• Kinetic and thermodynamic analyses indicated favorable surface conditions for heparin adsorption.
• Adsorption parameters and sorbent reusability were assessed for process refinement.

Conclusions:

• CBV901 zeolite shows significant potential as an efficient and cost-effective adsorbent for heparin extraction.
• The study provides valuable insights into zeolite-based heparin recovery processes.
• Further optimization could enhance the industrial applicability of this method.