Related Experiment Video

Updated: May 3, 2026

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
12:52

Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells

Published on: November 28, 2015

15.8K

Research Progress of NK Cells in Glioblastoma Treatment

Hao Wu1, Qi Liu2, Fenglu Wang1

  • 1Department of Neurosurgery, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, People's Republic of China.

Oncotargets and Therapy
|January 23, 2025
PubMed

Insights

Natural killer (NK) cells show promise for glioma immunotherapy, but the tumor microenvironment

Area of Science:

  • Immunology
  • Oncology
  • Cancer Research

Background:

  • Natural killer (NK) cells are crucial antitumor immune cells.
  • Glioma's immunosuppressive microenvironment hinders NK cell immunotherapy efficacy.

Purpose of the Study:

  • Review the role of NK cells in glioma immunotherapy.
  • Discuss NK cell development, function, and localization in gliomas.
  • Explore strategies to enhance NK cell-based glioma treatment.

Main Methods:

  • Literature review of NK cell research in glioma.
  • Analysis of current therapies targeting NK cells.
  • Examination of gene-modified NK cell strategies.

Main Results:

  • NK cell activity is modulated by receptors and the tumor microenvironment.
  • Various therapies (compounds, antibodies, cytokines) are being investigated.
  • Gene-modified NK cells represent a promising therapeutic trend.

Conclusions:

  • Understanding NK cell dynamics in gliomas is key.
  • Targeting NK cells and overcoming immune escape mechanisms are crucial for effective glioma immunotherapy.
  • Gene-edited NK cells offer novel therapeutic avenues for gliomas.
Keywords:
glioblastomainhibitory factorssurvival ratestherapeutic strategies

More Related Videos

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds09:18

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Published on: July 16, 2018

8.2K
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts11:15

Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts

Published on: September 1, 2018

7.8K

Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.0K