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Related Concept Videos

Urinary Bladder01:23

Urinary Bladder

348
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
348
Disorders of the Urinary System01:20

Disorders of the Urinary System

229
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
229

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Related Experiment Video

Updated: May 31, 2025

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
08:43

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URINARY BLADDER PARAGANGLIOMA- A NOTEWORTHY, RARE ENTITY.

J N Bharti1

  • 1All India Institute of Medical Science, Department of Pathology & Lab Medicine, Mangalagiri, Guntur, India.

Acta Endocrinologica (Bucharest, Romania : 2005)
|January 23, 2025
PubMed
Summary

Urinary bladder paraganglioma is a rare tumor presenting as hematuria. This case report details a 70-year-old male diagnosed with bladder paraganglioma, emphasizing the need for long-term follow-up due to malignancy risk.

Keywords:
neoplasmneuroendocrineparagangliomaurinary bladder

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Area of Science:

  • Urology
  • Oncology
  • Pathology

Background:

  • Urinary bladder paraganglioma is an exceptionally rare tumor, constituting only 0.06% of all bladder neoplasms.
  • These tumors can occur sporadically or be linked to hereditary syndromes like Hereditary Paraganglioma-Pheochromocytoma Syndrome.
  • Common clinical presentations include painless hematuria and micturition syncope.

Observation:

  • A 70-year-old male presented with hematuria, leading to the discovery of an enhancing bladder mass via CT scan.
  • Histopathological analysis revealed tumor cells in a characteristic Zellballen pattern with specific immunohistochemical markers (Synaptophysin, S-100P positive; CK7 negative).

Findings:

  • The resected bladder mass was confirmed as a paraganglioma based on its distinct histological and immunohistochemical profile.
  • The patient experienced a favorable outcome two years post-surgery, with no signs of recurrence.

Implications:

  • The rarity of bladder paraganglioma limits established treatment and monitoring guidelines.
  • Despite its rarity, the potential for malignancy necessitates vigilant long-term surveillance and early diagnostic interventions such as cystoscopy, TURB, and imaging.