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Fructose-Modified Chitosan/Gelatin 3D Composite Sponge for Enhanced Rapid Hemostasis
Hongyan Wang1, Lin Shi1, Zhongxu Zhang2
1Institute of Chemicobiology and Functional Materials, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, 200 Xiao Ling Wei, Nanjing, Jiangsu Province 210094, China.
Biomacromolecules
|January 23, 2025
Summary
A new fructose-modified chitosan/gelatin sponge effectively stops severe bleeding in trauma care. This innovative material rapidly expands and promotes healing by reducing inflammation, offering a promising solution for noncompressible bleeding injuries.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Emergency Medicine
Background:
- Uncontrolled, noncompressible bleeding is a critical challenge in emergency trauma care.
- Developing rapid hemostatic methods without direct pressure is a key research area.
- Advanced wound management materials are needed for severe injuries.
Purpose of the Study:
- To develop and evaluate a novel fructose-modified chitosan/gelatin composite sponge for hemostasis.
- To assess the material's physical properties, including elasticity and water responsiveness.
- To investigate the hemostatic efficacy and tissue healing promotion of the composite sponge.
Main Methods:
- Fabrication of a fructose-modified chitosan/gelatin composite sponge.
- Evaluation of material properties: elasticity, rebound pressure, and water-induced expansion.
- In vivo testing on a rat liver wound model to assess hemostatic performance.
- Analysis of inflammatory markers (TNF-α, MCP-1, IL-6) to evaluate tissue healing potential.
Main Results:
- The composite sponge demonstrated high elasticity, low rebound pressure, and rapid water-induced expansion (1.5s).
- Significant reduction in hemostatic time (204s to 53.3s) and blood loss (867mg to 187mg) in a rat liver wound model.
- Inhibition of key inflammatory factors (TNF-α, MCP-1, IL-6), indicating enhanced tissue healing.
- Excellent cell compatibility was observed.
Conclusions:
- The fructose-modified chitosan/gelatin composite sponge is a highly effective hemostatic agent for noncompressible bleeding.
- The material's rapid expansion and anti-inflammatory properties facilitate wound healing.
- This novel biomaterial presents a promising solution for managing severe trauma-related hemorrhage.
