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Updated: May 31, 2025

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Claudins as diagnostic tools and therapeutic targets-Glimpse of the horizon

Keiji Sugiyama1, Ian Chau2

  • 1Gastrointestinal Unit, Department of Medicine, Royal Marsden Hospital, London and Surrey, UK; Department of Medical Oncology, NHO Nagoya Medical Center, Nagoya, Aichi, Japan.

Cancer Treatment Reviews
|January 23, 2025
PubMed

Insights

Claudins (CLDNs) are key tight junction proteins. Their unique expression in normal and cancerous tissues makes them promising targets for cancer diagnosis and therapy, with recent clinical trials showing advancements.

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Biology

Background:

  • Claudins (CLDNs) are integral membrane proteins forming the backbone of tight junctions.
  • Tight junctions regulate paracellular permeability and maintain cell polarity.
  • Aberrant CLDN expression is a hallmark of many human cancers.

Purpose of the Study:

  • To provide a comprehensive review of Claudins (CLDNs) in cancer.
  • To elucidate the role of CLDNs in cancer diagnosis and therapeutic strategies.
  • To summarize recent advancements and clinical trial outcomes related to CLDNs.

Main Methods:

  • Literature review of fundamental Claudin (CLDN) biology.
  • Analysis of CLDN expression patterns in normal and malignant tissues.
  • Synthesis of data from preclinical studies and clinical trials involving CLDNs.

Main Results:

  • Claudins (CLDNs) exhibit diverse expression profiles correlating with tissue type and malignancy.
  • Specific CLDNs are validated as diagnostic biomarkers for various cancers.
  • Targeting CLDNs shows potential for novel systemic anti-cancer therapies.

Conclusions:

  • Claudins (CLDNs) are critical regulators of tight junction integrity and cellular function.
  • Their distinct expression patterns offer significant opportunities for cancer biomarker development.
  • CLDN-targeted therapies represent a promising frontier in oncology, supported by emerging clinical evidence.
Keywords:
AntibodyAntibody-drug conjugatesCancer treatmentClaudinchimeric antigen receptor T cells

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