Comparing the Robustness of Intensity-modulated Proton Therapy and Proton-arc Therapy Against Interplay Effects of 4D...

To assess the robustness of 4D-optimised IMPT and PAT plans against interplay effects in non-small cell lung cancer (NSCLC) patients with respiratory motion over 10 mm, and to provide insights into the use of proton-based stereotactic body radiotherapy (SBRT) for lung cancer with significant tumour movement.

Fourteen patients with early-stage NSCLC and tumour motion >10 mm were selected. Three hypofraction regimens were generated using 4D robust optimisation with the IMPT and PAT techniques. The nominal plan qualities for both techniques were compared, and their robustness against setup and range uncertainties was evaluated. 4D dynamic dose and the 4D static dose were generated to calculate ΔI_M^R(%) for interplay effects.

PAT plans demonstrated superior target metrics such as D₉₅ and D₂, and offered enhanced protection for organs at risk (OARs), particularly in lung metrics, across multiple fractionation schemes (p < 0.05). The robustness of target coverage against setup and range uncertainties was better in PAT plans than IMPT, with average pass rates of 97.8% and 95.4%, respectively (p < 0.01). The interplay effect significantly affected target metrics in single-fraction plans, decreasing with more fractions, while its effect on OAR metrics was minimal. Median values for single-fraction plans were: ΔI_D98^GTV was -3% for IMPT and -0.7% for PAT (p < 0.01); ΔI_D95^GTV was -2.4% for IMPT and -0.6% for PAT (p < 0.01); ΔI_D2^GTV was 3.2% for IMPT and 0.9% for PAT (p < 0.05). The interplay effects resulted in median homogeneity index deviations of 9.1% and 2% for the IMPT and PAT plans, respectively (p < 0.01). Different starting phases affected IMPT more significantly than PAT.

PAT demonstrated greater robustness to interplay effects than IMPT for hypofractionated treatments of early-stage NSCLC, particularly in single-fraction schemes. Additionally, PAT showed good resilience to variations in different starting phases.