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Cardiovascular disease and bipolar disorder: A review of pathophysiology and treatment implications

Mayuresh Chaudhari1, Luis Mendez1, Rene L Olvera2

  • 1The Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

International Journal of Psychiatry in Medicine
|January 23, 2025
PubMed

Insights

Individuals with bipolar disorder (BD) face higher cardiovascular risks due to shared biological and lifestyle factors. Integrated care is crucial for managing both cardiovascular and psychiatric health in BD patients.

Area of Science:

  • Psychiatry
  • Cardiology
  • Public Health

Background:

  • Bipolar disorder (BD) is associated with significantly increased cardiovascular mortality.
  • Cardiovascular risk factors and diseases are often overlooked in BD patients.
  • Shared pathophysiological mechanisms link BD and cardiovascular diseases.

Purpose of the Study:

  • To review the pathophysiological basis of the BD-cardiovascular disease connection.
  • To highlight shared mechanisms and reciprocal interactions.
  • To discuss prevention and treatment strategies for cardiovascular risk in BD.

Main Methods:

  • A narrative review was conducted.
  • Literature search performed on PubMed.
  • Keywords included: bipolar disorder, cardiovascular diseases, cardiovascular risk factors.

Main Results:

  • Overlapping biological and psychosocial mechanisms contribute to cardiovascular morbidity in BD.
  • BD directly and indirectly impacts cardiovascular health via lifestyle and medications.
  • Cardiovascular diseases worsen BD clinical course, increasing morbidity and costs.

Conclusions:

  • Effective management of cardiovascular diseases can improve psychiatric outcomes in BD.
  • Healthcare barriers for BD patients require addressing.
  • Awareness initiatives and integrated care research are essential for improving outcomes.
Abstract

Keywords:
antipsychoticsbipolar disorderscardiovascular diseasesmetabolic syndrome

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