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Updated: May 29, 2026
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
The use of machine learning approaches for mortality prediction and classification in traumatic brain injury: a
Arthur Afonso Silva-Sousa1, Fernanda Carolina Camargo2, Leopoldo Mandic F Furtado1
1Universidade Federal de Minas Gerais (UFMG), Instituto de Ciências Biológicas, Programa de Pós-graduação em Neurociências, Av. Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
Objective:
This systematic review analyzed machine learning (ML) techniques for predicting and classifying mortality in traumatic brain injury (TBI) victims.
Methods:
The PICOS (People, Intervention, Comparison, Outcome, Study) strategy was used for the research question. The included studies were indexed in the Virtual Health Library and the National Library of Medicine, written in English, Portuguese, or Spanish, and focused on TBI-related mortality. Exclusions comprised animal studies, molecular research, reviews, and unavailable full texts.
Results:
Of 1,752 screened studies, 36 met inclusion criteria. Most publications emerged in 2023 (n = 10, 27.8%), with the highest number of publications belonging to Asian countries (n = 12, 33.3%). The general mean age of TBI was 50.5 years for male adults and the main causes were motor vehicle accidents and falls. The main predictors of mortality were low Glasgow Coma Scale score (n=17, 12.9%) and age (n=14, 10.6%). The best machine learning techniques to predict mortality were Support Vector Machine, Logistic Regression, Random Forest and eXtreme Gradient Boosting. The areas under the curve (AUC) ranged from 0.757 to 0.968.
Conclusion:
Machine learning techniques seem to be useful and promising tools for predicting mortality in TBI victims, and thus help in clinical decisions.
