Dietary proteins from various sources have different effects on short-term food intake and intestinal hormone...

Besides their nutritional role, proteins are recognized for their ability to regulate both short- and long-term energy homeostasis. However, studies investigating the effects of proteins based on their quality and origin remain limited and often lack comparability. Nonetheless, existing research consistently underscores the influence of proteins on food intake regulation. Additionally, digested proteins promote satiety by stimulating the secretion of intestinal hormones. This study aimed to compare the effects of proteins from different origins (hemoglobin, caseins, ovalbumin, whey proteins, fish gelatin, pea proteins and gluten proteins) on short-term food intake using Wistar rats in metabolic cages. Proteins were then digested using in vitro static INFOGEST protocol to assess their effects on intestinal hormone secretion using STC-1 cells. The results revealed distinct impacts of these proteins on short-term food intake, respiratory exchange ratio, but also on GLP-1 and CCK secretion. This study demonstrates the impact of various proteins on energy homeostasis by affecting the regulation of short-term food intake, which correlates with the modulation of intestinal hormone secretion. The findings also emphasize the role of protein origin in these mechanisms, with whey, pea, and gluten emerging as the most effective. Differences in satiety among proteins can be attributed to variations in digestibility rates and effects on intestinal hormone secretion, indicating that dietary proteins regulate food intake in a manner dependent on both their nature and origin.