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Dual Blood Purification with CytoSorb and oXiris in Managing Recurrent Septic Shock: A Case Report
Bartłomiej Włochacz1, Andrzej Rybak1, Agnieszka Próchnicka1
1Department of Anesthesiology and Intensive Care, Legionowo Hospital, Military Institute of Medicine - National Research Institute, Warsaw, Poland.
The American Journal of Case Reports
|January 24, 2025
Summary
This case report suggests that combining CytoSorb hemoadsorption with oXiris continuous renal replacement therapy may improve outcomes for patients with recurrent septic shock, reducing inflammatory markers and aiding recovery.
Area of Science:
- Critical Care Medicine
- Nephrology
- Immunology
Background:
- Sepsis management often requires adjunctive extracorporeal blood purification.
- CytoSorb is a medical device for reducing inflammatory cytokines.
- oXiris is a high-adsorption membrane filter for continuous hemofiltration adsorption.
Purpose of the Study:
- To describe a case of recurrent septic shock treated with CytoSorb and oXiris.
- To evaluate the potential benefits of these adjunctive therapies in a critically ill patient.
Main Methods:
- A 67-year-old male patient with recurrent septic shock was treated with antibiotics, vasopressors, inotropes, mechanical ventilation, and continuous renal replacement therapy (CRRT).
- Adjunctive therapy included CRRT with an oXiris filter and CytoSorb hemadsorption.
- Patient's condition and inflammatory markers (procalcitonin, CRP) were monitored.
Main Results:
- Rapid clinical improvement was observed after initiating CRRT with the oXiris filter and CytoSorb adsorber.
- Significant decreases in procalcitonin and C-reactive protein (CRP) levels were noted.
- The patient was discharged from the Intensive Care Unit (ICU) within 5 days of therapy initiation.
Conclusions:
- While large clinical trial data are lacking, this case supports the use of CytoSorb and oXiris as potential adjunctive treatments for sepsis.
- These devices may help manage severe sepsis and septic shock by reducing inflammatory burden.
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