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Related Experiment Video

Updated: May 5, 2026

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Glycemic control after aortic valve replacement: A retrospective study.

Yuval Avidan1, Amir Aker1, Ibrahim Naoum1

  • 1Department of Cardiology, Lady Davis Carmel Medical Center, Haifa, Israel.

International Journal of Cardiology. Heart & Vasculature
|January 24, 2025
PubMed
Summary

Aortic valve replacement (AVR) improves glycemic control in patients with diabetes. Transcatheter aortic valve implantation (TAVI) showed a trend toward greater improvement compared to surgical aortic valve replacement (SAVR).

Keywords:
Aortic stenosisDiabetesGlycemic controlSurgical aortic valve replacementTranscatheter aortic valve implantation

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Area of Science:

  • Cardiology
  • Endocrinology
  • Inflammation Research

Background:

  • Aortic stenosis (AS) is a common condition treated by transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR).
  • Diabetes mellitus is highly prevalent in patients undergoing aortic valve replacement (AVR).
  • Inflammation plays a role in AS pathogenesis, and TAVI may possess anti-inflammatory properties, suggesting a potential impact on glycemic control in diabetic patients.

Purpose of the Study:

  • To investigate the effect of aortic valve replacement (AVR) on glycemic control in patients with diabetes.
  • To compare the impact of TAVI versus SAVR on glycated hemoglobin (HbA1c) levels.

Main Methods:

  • Retrospective analysis of 10,129 patients undergoing TAVI or SAVR from January 2010 to January 2022.
  • Focus on 1,284 patients with diabetes and pre- and post-procedural HbA1c measurements (HbA1c ≥ 7%).
  • Propensity-score matching created comparable cohorts of 266 TAVI and 266 SAVR patients for analysis.

Main Results:

  • Overall HbA1c significantly decreased from 8.15% to 7.88% (p < 0.001) in the cohort of 1,284 patients.
  • In matched cohorts, TAVI patients showed a significant HbA1c reduction from 8.31% to 7.86% (p < 0.001).
  • SAVR patients exhibited a modest HbA1c decrease from 8.33% to 8.15% (p = 0.046), with TAVI showing a trend toward greater improvement (p = 0.051).

Conclusions:

  • Both TAVI and SAVR improve glycemic control in patients with uncontrolled diabetes undergoing AVR.
  • The glycemic improvement appeared more pronounced in the TAVI group.
  • Further prospective studies are warranted to confirm these findings and elucidate the mechanisms involved.