Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Creating smaller eyedrops by reducing eyedropper tip dimensions.

R H Brown, M L Hotchkiss, E B Davis

    American Journal of Ophthalmology
    |April 15, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Soft Foil and Progressive Dentistry.

    International dental journal (Philadelphia, Pa.)·2023
    Same author

    Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele.

    Neurology·2007
    Same author

    Genetic variability of induction and emergence times for inhalational anaesthetics.

    European journal of anaesthesiology·2007
    Same author

    Surface composition of Hyperion.

    Nature·2007
    Same author

    The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis.

    Cell death and differentiation·2007
    Same author

    Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma.

    The European respiratory journal·2007
    Same journal

    Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

    American journal of ophthalmology·2026
    Same journal

    Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

    American journal of ophthalmology·2026
    Same journal

    Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

    American journal of ophthalmology·2026
    Same journal

    Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

    American journal of ophthalmology·2026
    See all related articles

    Reducing eyedrop volume minimizes systemic absorption and toxicity risks. Smaller eyedrops (11-25 microliters) achieve effective tear film concentration, enhancing patient safety in ophthalmic treatments.

    Area of Science:

    • Ophthalmology
    • Pharmaceutics
    • Biomedical Engineering

    Background:

    • Conventional eyedrops (50-70 microliters) exceed normal tear film capacity (7-10 microliters).
    • Excess eyedrop volume leads to nasolacrimal drainage and systemic absorption.
    • Systemic absorption of eyedrop components can cause toxicity and adverse effects.

    Purpose of the Study:

    • To investigate the relationship between eyedropper tip dimensions and eyedrop volume.
    • To determine if smaller eyedrop volumes can be reliably produced.
    • To reduce the risk of toxicity and systemic effects associated with ophthalmic medications.

    Main Methods:

    • Modification of the outer and inner diameters of an eyedropper tip.
    • Measurement of resultant eyedrop volumes.

    Related Experiment Videos

  • Analysis of potential for maximal tear film concentration with reduced systemic absorption.

    • Main Results:

    • Eyedropper tip dimensions significantly alter eyedrop volume.
    • Production of eyedrops with volumes less than 25 microliters achieved.
    • Demonstrated ability to produce eyedrops as small as 11 microliters.

    Conclusions:

    • Optimizing eyedropper tip design allows for significant reduction in eyedrop volume.
    • Smaller eyedrops can achieve therapeutic tear film concentrations with reduced systemic absorption.
    • This approach offers a strategy to enhance patient safety by minimizing ocular drug toxicity.