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Cadaveric renal graft acceptance without azathioprine
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
|January 1, 1979
Summary
Discontinuing azathioprine did not impact serum creatinine levels in most kidney transplant recipients with good function. Azathioprine appears ineffective for managing chronic renal rejection.
Area of Science:
- Nephrology
- Immunosuppression
- Transplant Medicine
Background:
- Azathioprine is an immunosuppressive medication used in organ transplantation.
- Its efficacy in long-term graft acceptance and chronic renal rejection is debated.
Purpose of the Study:
- To evaluate the impact of azathioprine withdrawal on kidney transplant recipients.
- To assess the role of azathioprine in managing chronic renal rejection.
Main Methods:
- Observational study of kidney transplant patients.
- Monitoring of serum creatinine levels before and after azathioprine withdrawal.
- Analysis of transplant function using serum creatinine and time relationships.
Main Results:
- Serum creatinine levels remained stable in most patients with good transplant function after azathioprine withdrawal.
- Azathioprine withdrawal did not alter the rate of function loss in patients with chronic rejection.
- Five out of seven patients with good graft function showed no significant change in serum creatinine post-withdrawal.
Conclusions:
- Azathioprine withdrawal may be compatible with long-term kidney transplant acceptance.
- Azathioprine appears to have limited benefit in managing chronic renal rejection.