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Burden of Gastric Cancer in China from 1990 to 2023
Xin Liu1, Shuqiang Cheng2, Hanlin Yang3
1Department of Clinical Laboratory, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
Objectives:
To comprehensively assess the gastric cancer burden in China over the past three decades and analyze its epidemiological trends to inform control strategies.
Study Design:
This was a population-based observational study that systematically evaluated the burden of gastric cancer in China from 1990 to 2023, utilizing data from the Global Burden of Disease (GBD) 2023 study.
Methods:
We evaluated gastric cancer burden metrics from GBD 2023, including incidence, mortality, YLLs, YLDs, and DALYs. Joinpoint regression and age-period-cohort modeling were employed to analyze trends and epidemiological characteristics.
Results:
Between 1990 and 2023, the age-standardized incidence rate decreased from 54.23 to 25.04 per 100,000 , and mortality decreased from 50.93 to 16.62 per 100,000. Joinpoint analysis showed an average annual percentage change of -2.8% in incidence, with a significant trend reversal in females during 2020-2023. Age-period-cohort analysis revealed peak risk at 65-69 years and lower risk in recent birth cohorts.
Conclusions:
While China has achieved substantial reductions in gastric cancer burden over 34 years, emerging challenges include trend reversals in females and persistent sex disparities, necessitating targeted prevention strategies.
