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Related Concept Videos

Salivary Glands and Saliva01:23

Salivary Glands and Saliva

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The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
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Exocrine Glands: Types of Secretions01:13

Exocrine Glands: Types of Secretions

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Exocrine glands produce and release a variety of glandular products. Exocrine glands can be classified into serous, mucous, or mixed types based on their secretory products.
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...
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Accessory Organs01:31

Accessory Organs

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Accessory organs are those that participate in the digestion of food but do not come into direct contact with it like the mouth, stomach, or intestine do. Accessory organs secrete enzymes into the digestive tract to facilitate the breakdown of food.
68.6K
Oral Cavity01:11

Oral Cavity

408
The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
408
Physiology of the Gastrointestinal System I: Ingestion and Propulsion01:22

Physiology of the Gastrointestinal System I: Ingestion and Propulsion

248
The physiology of the gastrointestinal system begins with ingestion as food enters the mouth.
248
Exocrine Glands: Methods of Secretion01:08

Exocrine Glands: Methods of Secretion

3.9K
Exocrine glands are those that release their secretions through ducts. Based on their mode of secretion, they can be classified into merocrine, apocrine, and holocrine.
Merocrine Secretion
Merocrine secretion is the most common type of exocrine secretion. The secretions are enclosed in vesicles and moved to the cell's apical surface, where the contents are released by exocytosis. For example, mucous, a watery secretion rich in the glycoprotein mucin, is a merocrine secretion. The eccrine...
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Updated: May 31, 2025

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
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Salivary Glands: Function, Dysfunction, Regeneration, and Repair.

Marco Tatullo1,2,3, Gianfranco Favia4, Nicola Antonio Adolfo Quaranta1

  • 1Department of Translational Biomedicine and Neuroscience - DiBraiN, University of Bari "Aldo Moro", 70124 Bari, Italy.

Discovery Medicine
|January 24, 2025
PubMed
Summary
This summary is machine-generated.

Salivary gland dysfunction impacts oral and systemic health. Advanced biotechnologies like stem cells and organoids offer promising strategies for salivary gland regeneration and repair.

Keywords:
oral medicineregenerative medicinesalivary glandstissue engineeringtranslational medicine

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Author Spotlight: Studying Macrophage-Epithelial Cell Interactions in Salivary Gland Regeneration After Injury
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Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
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Author Spotlight: Studying Macrophage-Epithelial Cell Interactions in Salivary Gland Regeneration After Injury
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Area of Science:

  • Biotechnology
  • Regenerative Medicine
  • Oral Biology

Background:

  • Salivary gland dysfunctions are prevalent, affecting oral and systemic health.
  • Aging and inflammation are key factors contributing to salivary gland dysfunction.
  • Current therapeutic strategies aim to regenerate, repair, or replace salivary gland tissue.

Purpose of the Study:

  • To review modern biotechnologies for salivary gland regeneration.
  • To explore advanced strategies including stem cells, tissue engineering, and organoids.
  • To understand the impact of salivary gland dysfunction on overall health.

Main Methods:

  • Literature review of tissue engineering, biomimetic strategies, and 3D organoids.
  • Analysis of stem cell applications in salivary gland repair.
  • Examination of allogeneic stem cell transplantation.

Main Results:

  • Stem cells, tissue engineering, and organoids show potential for salivary gland regeneration.
  • Allogeneic stem cell transplantation is a viable solution for current limitations.
  • Optimizing long-term maintenance of these advanced approaches is necessary.

Conclusions:

  • Modern biotechnologies offer significant advancements in salivary gland repair.
  • Stem cells and organoids are key components in future therapeutic strategies.
  • Further research is needed to refine these techniques for clinical application.