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Modeling the Effect of Cannabinoid Exposure During Human Neurodevelopment Using Bidimensional and Tridimensional
Enrique Estudillo1, Jorge Iván Castillo-Arellano1, Emilio Martínez1,2
1Laboratorio de Reprogramación Celular, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.
Cells
|January 24, 2025
Summary
Cannabinoid use during pregnancy may impact fetal neurodevelopment. Human stem cell models offer a way to study these effects without confounding factors, providing crucial insights into brain development risks.
Area of Science:
- Neuroscience
- Developmental Biology
- Pharmacology
Background:
- Evidence on cannabinoid consumption during pregnancy and its effects on neurodevelopment is inconsistent.
- Confounding factors in pregnant women complicate the study of cannabinoid effects on fetal development.
Purpose of the Study:
- To review clinical studies on exogenous cannabinoid consumption and human brain development.
- To explore how cannabinoids affect nervous system development using human pluripotent stem cells.
Main Methods:
- Utilizing human pluripotent stem cells (hPSCs) to model human neurodevelopment in vitro.
- Employing 2D and 3D cell culture platforms to recapitulate brain development.
- Reviewing existing clinical studies on cannabinoid exposure during pregnancy.
Main Results:
- Human pluripotent stem cell models provide a viable alternative to study cannabinoid effects without ethical concerns or confounding variables.
- These models allow for detailed investigation into the mechanisms by which exogenous cannabinoids may alter neurodevelopment.
Conclusions:
- Human pluripotent stem cell platforms are crucial for understanding the impact of cannabinoids on neurodevelopment.
- Further research using these models is needed to clarify the risks associated with prenatal cannabinoid exposure.
