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Updated: May 31, 2025

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Recent Advances in Metal-Organic Framework-Based Anticancer Hydrogels.

Preeti Kush1, Ranjit Singh1, Parveen Kumar2

  • 1Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University Gangoh, Saharanpur 247341, Uttar Pradesh, India.

Gels (Basel, Switzerland)
|January 24, 2025
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Summary
This summary is machine-generated.

Metal-organic frameworks (MOFs) conjugated with hydrogels offer improved cancer theranostics. These MOF-based hydrogels enhance drug delivery and controlled release for effective cancer management with fewer side effects.

Keywords:
challengeschemotherapyhydrogelmetal–organic framework

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cancer Research

Background:

  • Cancer poses a significant global health challenge, driving the need for advanced therapeutic strategies.
  • Metal-organic frameworks (MOFs) show promise for cancer theranostics and drug delivery but face limitations like aggregation and poor dispersibility.
  • Conjugating MOFs with polymeric hydrogels addresses these limitations, creating flexible, mechanically robust materials.

Purpose of the Study:

  • To review synthesis and characterization strategies for MOF-based hydrogels.
  • To highlight recent advancements in MOF-based hydrogels for cancer management.
  • To discuss challenges and future directions in the field.

Main Methods:

  • Synthesis of MOF-based hydrogels via conjugation of MOFs with polymeric hydrogels.
  • Characterization of the resulting MOF-based hydrogels.
  • Review of literature on the application of these hydrogels in cancer theranostics.

Main Results:

  • MOF-based hydrogels exhibit enhanced properties such as abundant absorption sites, flexibility, and improved mechanical strength.
  • These materials facilitate efficient drug delivery and controlled release for cancer treatment.
  • Recent studies demonstrate the potential of MOF-based hydrogels in managing various types of cancer.

Conclusions:

  • MOF-based hydrogels represent a promising platform for developing advanced cancer therapies.
  • Further research can optimize these materials for augmented anticancer effects and reduced adverse effects.
  • This review provides insights for developing novel MOF-based hydrogels for effective cancer management.