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Updated: May 31, 2025

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Nano Delivery System for Atherosclerosis.

Zhuoyi Rong1, Xuan He1, Tianjian Fan1

  • 1Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang 421001, China.

Journal of Functional Biomaterials
|January 24, 2025
PubMed
Summary
This summary is machine-generated.

Nanoparticles offer improved safety and efficacy for atherosclerosis drug delivery, addressing limitations of current therapies. This review explores nanoparticle advancements, challenges, and future directions in cardiovascular disease treatment.

Keywords:
atherosclerosisatherosclerotic plaquenanomaterialnanoparticletheranostics

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Area of Science:

  • Cardiovascular Science
  • Biomedical Engineering
  • Pharmacology

Background:

  • Atherosclerosis is a major cause of cardiovascular disease, driven by inflammation and lipids.
  • Current drug therapies for atherosclerosis have limitations including poor stability and side effects.
  • Nanomaterials are emerging as promising tools for targeted drug delivery.

Purpose of the Study:

  • To review the role of nanoparticles in enhancing drug safety and efficacy for atherosclerosis.
  • To discuss the development and optimization of nanoparticle-based drug delivery systems.
  • To explore current challenges and future opportunities in nanoparticle applications for atherosclerosis.

Main Methods:

  • Literature review of nanoparticle-based drug delivery systems for atherosclerosis.
  • Analysis of studies focusing on liposomes and polymeric nanoparticles.
  • Discussion of nanoparticle optimization strategies and clinical translation.

Main Results:

  • Nanoparticles demonstrate potential to improve drug stability and reduce side effects in atherosclerosis treatment.
  • Various nanoparticle formulations show promise for targeted delivery of therapeutic agents.
  • Ongoing research focuses on optimizing nanoparticle design and manufacturing.

Conclusions:

  • Nanoparticle-based drug delivery represents a significant advancement in atherosclerosis therapy.
  • Further research and development are needed to overcome challenges in clinical application.
  • Nanomaterials hold considerable promise for future cardiovascular disease management.