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MoS2-Plasmonic Hybrid Platforms: Next-Generation Tools for Biological Applications.

Nayra A M Moussa1, Seungah Lee2, Seong Ho Kang2

  • 1Basic and Clinical Medical Science Department, Faculty of Dentistry, Deraya University, New Minya 61768, Egypt.

Nanomaterials (Basel, Switzerland)
|January 24, 2025
PubMed
Summary

Molybdenum disulfide (MoS2)-plasmonic hybrids offer advanced biosensing, bioimaging, and phototherapy by combining MoS2

Keywords:
MoS2–plasmonic hybridsbioimagingbiosensingphototherapy

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Area of Science:

  • Nanotechnology and Materials Science
  • Biomedical Engineering
  • Optoelectronics

Background:

  • Molybdenum disulfide (MoS2) offers biocompatibility and high surface area.
  • Plasmonic nanomaterials provide high optical sensitivity.
  • Combining these creates MoS2-plasmonic hybrid systems for enhanced biological applications.

Purpose of the Study:

  • To review synthesis strategies for MoS2-plasmonic hybrids.
  • To explore applications in biosensing, bioimaging, and phototherapy.
  • To discuss challenges and future directions for clinical translation.

Main Methods:

  • Exploration of synthesis strategies: seed-mediated growth, in situ deposition, heterojunction formation.
  • Analysis of hybrid system properties for signal amplification and targeted therapies.
  • Review of applications in cancer/infectious disease biomarker detection and cellular imaging.

Main Results:

  • MoS2-plasmonic hybrids enhance signal amplification for sensitive detection and detailed imaging.
  • Tailored configurations enable selective photothermal/photodynamic therapies with minimal off-target effects.
  • Promising potential demonstrated for accurate tumor ablation via light-induced mechanisms.

Conclusions:

  • MoS2-plasmonic hybrids show significant promise for next-generation diagnostics and targeted therapies.
  • Overcoming challenges in reproducibility, toxicity, stability, delivery, and manufacturing is crucial for clinical translation.
  • Further research is essential to realize the full potential of these hybrid systems in medicine.