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Updated: May 11, 2026

The Use of a β-lactamase-based Conductimetric Biosensor Assay to Detect Biomolecular Interactions
Published on: February 1, 2018
[β-Lactam Hypersensitivity: Narrative Review and an Inpatient Management Algorithm Proposal]
Patricio Ross1, Tomás Reyes-Barros1, María Teresa Peralta1
1Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Abstract:
β-Lactam hypersensitivity is the most frequently self-reported drug hypersensitivity reaction. However, most of these patients are not truly allergic. The label of B. Lactam allergy is associated with multiple adverse outcomes, including mortality, increased costs, and hospital stay; therefore, healthcare practitioners should try to eliminate this label, when possible, in addition to knowing what safe antibiotic alternatives exist depending on the degree of risk, if the allergy is confirmed.
Aim:
This review presents the most critical aspects of β-lactams allergy regarding relevance, pathophysiological mechanisms, diagnosis, and management, emphasizing cross-reaction risk.
Methods:
Narrative review of literature.
Conclusion:
According to the literature review results, we propose a management algorithm for hospitalized patients.
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