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[Amphotericin B Liposomal Lock Therapy in Fungal Peritonitis in a Patient With Peritoneal Dialysis: Regarding a

Eduardo Ávila1, Lucy Abarzúa1, Belén Gallardo1

  • 1Unidad de Diálisis Peritoneal, Departamento de Nefrología, Pontificia Universidad Católica de Chile, Santiago, Chile.

Revista Medica De Chile
|January 24, 2025
PubMed

Insights

Fungal peritonitis, a rare peritoneal dialysis complication, may benefit from intracatheter liposomal amphotericin B lock therapy. This approach, combined with catheter removal, offers a potential alternative management strategy.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • Fungal peritonitis is a rare but serious complication of peritoneal dialysis (PD).
  • Standard treatment involves systemic antifungal agents and early PD catheter removal.
  • Limited data exists on alternative or adjunctive therapies for PD-related fungal peritonitis.

Observation:

  • This report details a clinical case of fungal peritonitis in a patient undergoing peritoneal dialysis.
  • The case involved the application of intracatheter lock therapy using liposomal amphotericin B.
  • The management strategy combined lock therapy with the established practice of PD catheter removal.

Findings:

  • The study analyzes the use of intracatheter liposomal amphotericin B as a lock therapy for fungal peritonitis.
  • This targeted antifungal approach was administered directly into the PD catheter.
  • The findings contribute to understanding the efficacy and application of localized antifungal treatment in PD infections.

Implications:

  • Intracatheter liposomal amphotericin B lock therapy presents a potential adjunctive or alternative treatment for fungal peritonitis.
  • This localized therapy may enhance antifungal drug concentration at the infection site.
  • Further research is warranted to establish the role and optimal protocols for lock therapy in managing PD-related fungal infections.

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