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Scopolamine, morphine, and brain-stem auditory evoked potentials in awake monkeys
Anesthesiology
|April 1, 1985
Summary
Scopolamine and morphine sulfate did not significantly alter brain-stem auditory evoked potentials (BAEPs) in rhesus monkeys. This study found no changes in BAEP latency or amplitude after drug administration.
Area of Science:
- Neuroscience
- Pharmacology
- Primate Research
Background:
- Brain-stem auditory evoked potentials (BAEPs) are crucial for assessing auditory pathway function.
- Scopolamine and morphine are commonly used drugs with known neurological effects.
Purpose of the Study:
- To investigate the impact of scopolamine and morphine sulfate on BAEPs in rhesus monkeys.
- To determine if these drugs affect the latency and amplitude of auditory evoked potentials.
Main Methods:
- Ten unanesthetized rhesus monkeys were administered intravenous scopolamine (0.1 mg/kg and 0.32 mg/kg) and morphine sulfate (3.2 mg/kg).
- BAEPs were recorded at 3-minute and 30-minute intervals post-administration.
- Measurements included latency and amplitude of various BAEP components.
Main Results:
- No statistically significant changes were observed in the latency of BAEP components.
- No significant alterations were found in the amplitude of BAEP components.
- Both scopolamine and morphine sulfate showed no discernible effect on the measured BAEP parameters.
Conclusions:
- Scopolamine and morphine sulfate, at the tested doses, do not appear to significantly affect brain-stem auditory evoked potentials in rhesus monkeys.
- Further research may explore different dosages or other neurophysiological measures.