Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-resolution computed tomography in multiple sclerosis.

L Barrett, B Drayer, C Shin

    Annals of Neurology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Multifaceted roles of CCAR family proteins in the DNA damage response and cancer.

    Experimental & molecular medicine·2024
    Same author

    Laboratory and clinical impacts of an overnight laboratory service.

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2020
    Same author

    Quantitative ultrasound of the tongue: Echo intensity is a potential biomarker of bulbar dysfunction in amyotrophic lateral sclerosis.

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2020
    Same author

    Cognitive decline in association with hyposmia in idiopathic rapid eye movement sleep behavior disorder: a prospective 2-year follow-up study.

    European journal of neurology·2019
    Same author

    Sources of bias in Gorman critique of bias: again a need for more reasonable, valid conclusions with true dialogue.

    Psychological medicine·2017
    Same author

    PROSPER delivery of universal preventive interventions with young adolescents: long-term effects on emerging adult substance misuse and associated risk behaviors.

    Psychological medicine·2017
    Same journal

    Reply to "Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm".

    Annals of neurology·2026
    Same journal

    Clinical Value of Aneurysm Wall Enhancement in Unruptured Intracranial Aneurysm.

    Annals of neurology·2026
    Same journal

    Imaging of Neurovascular Compression in Thoracic Outlet Syndrome.

    Annals of neurology·2026
    Same journal

    Reply to "Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease".

    Annals of neurology·2026
    Same journal

    Methodological Challenges in Interpreting SAA-Defined Imaging Subgroups in Parkinson's Disease.

    Annals of neurology·2026
    Same journal

    The Financial Value of an Academic Neurologist.

    Annals of neurology·2026
    See all related articles

    Computed tomography (CT) scans reveal brain abnormalities in multiple sclerosis (MS) patients, correlating with disease severity and active inflammation. CT offers an objective tool for MS research and diagnosis.

    Area of Science:

    • Neurology
    • Radiology
    • Medical Imaging

    Background:

    • Multiple Sclerosis (MS) diagnosis relies on clinical and laboratory findings.
    • Objective imaging markers are needed to assess disease activity and progression.

    Purpose of the Study:

    • To evaluate the utility of computed tomography (CT) in diagnosing and assessing activity in multiple sclerosis.
    • To correlate CT findings with clinical classifications and disease exacerbations.

    Main Methods:

    • Eighty-five patients with definite, probable, or possible multiple sclerosis underwent enhanced CT scans.
    • Cerebrospinal fluid (CSF) and evoked response studies were performed concurrently.
    • CT findings, including focal decreased brain density and abnormal enhancement, were analyzed.

    Related Experiment Videos

    Main Results:

    • 62% of patients showed CT abnormalities; 29% had abnormal contrast enhancement.
    • Abnormal enhancement was significantly higher in definite MS and during clinical exacerbations (89%).
    • CT findings correlated with clinical exacerbation, unlike CSF studies.

    Conclusions:

    • Enhanced CT provides an in vivo, objective map of brain parenchyma and blood-brain barrier integrity in MS.
    • CT is valuable for research and aids in diagnosing suspected MS cases.
    • CT findings correlate with active inflammation in multiple sclerosis.