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Related Experiment Video

Updated: May 31, 2025

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
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E-Cigarette Use and Depression Among American Indian Adults Who Smoke.

Brady A Garrett1, Ashley L Comiford2, Justin D Dvorak3

  • 1Department of Public Health, Cherokee Nation, 1325 East Boone Street, Tahlequah, OK, 74464, USA. brady-garrett@cherokee.org.

Journal of Racial and Ethnic Health Disparities
|January 24, 2025
PubMed
Summary

E-cigarette use in American Indian (AI) adult smokers is linked to a higher likelihood of depression history. Further research is needed to understand the causal relationship between vaping, smoking, and depression.

Keywords:
American IndianCommercial tobaccoDepressionE-cigarette useHealth disparities

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Area of Science:

  • Public Health
  • Mental Health Research
  • Tobacco Control

Background:

  • Smoking remains a significant public health issue, particularly among American Indian (AI) populations.
  • Understanding the mental health comorbidities associated with smoking cessation aids, like e-cigarettes, is crucial.

Purpose of the Study:

  • To investigate the association between e-cigarette use and a history of depression among AI adult smokers.
  • To identify factors associated with depression in this demographic.

Main Methods:

  • Secondary data analysis of 375 AI adult smokers from a 2016 survey in Oklahoma.
  • Multivariable logistic regression was employed to assess the relationship between e-cigarette use and depression history, controlling for confounders.

Main Results:

  • Current and former e-cigarette users showed significantly higher odds of depression history compared to never users.
  • Strong nicotine cravings and a history of chronic disease were also independently associated with a history of depression.

Conclusions:

  • E-cigarette use is independently associated with a history of depression in AI adult smokers.
  • The directionality of the relationship between e-cigarette use, smoking, and depression requires further investigation using prospective designs.