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Lupoid sclerosis: a possible pathogenetic role for antiphospholipid antibodies
Annals of the Rheumatic Diseases
|April 1, 1985
Summary
A woman developed transverse myelitis, a neurological condition, over one year. High levels of IgM anticardiolipin antibodies suggested a lupus-like illness may have contributed to her condition.
Area of Science:
- Neurology
- Immunology
- Rheumatology
Background:
- Transverse myelitis is an inflammatory condition affecting the spinal cord.
- Lupus-like illnesses can present with diverse neurological manifestations.
- Anticardiolipin antibodies are associated with autoimmune disorders and thrombosis.
Observation:
- A 45-year-old woman presented with a year-long history of transverse myelitis.
- Serological testing indicated a lupus-like autoimmune process.
- High titers of IgM class anticardiolipin antibodies were identified in her serum.
Findings:
- The patient's transverse myelitis developed over a one-year period.
- Diagnostic workup revealed serological evidence consistent with a lupus-like illness.
- Significantly elevated IgM anticardiolipin antibodies were detected.
Implications:
- IgM anticardiolipin antibodies may play a role in the pathogenesis of transverse myelitis in certain autoimmune conditions.
- This case highlights the potential link between specific autoantibodies and neurological inflammation.
- Further research may elucidate the mechanisms by which these antibodies contribute to myelitis.