Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nortriptyline-induced severe hyperventilation.

S Sunderrajan, C S Brooks, E V Sunderrajan

    Archives of Internal Medicine
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Some Perversions of the Sexual Instinct.

    Journal of the National Medical Association·2010
    Same author

    Cerecyte versus platinum coils in the treatment of intracranial aneurysms: packing attenuation and clinical and angiographic midterm results.

    AJNR. American journal of neuroradiology·2009
    Same author

    Pulmonary perivascular and interstitial inflammation in MRL/MpJ-lpr/lpr mice. III. Modulation by cyclophosphamide and sex hormones in 4- and 6-month-old animals.

    Clinical immunology and immunopathology·1991
    Same author

    Cost effectiveness and accuracy of renal scans in the management of patients undergoing renal transplantation.

    The International journal of artificial organs·1989
    Same author

    Systemic mastocytosis associated with membranous nephropathy and peripheral neuropathy.

    American journal of kidney diseases : the official journal of the National Kidney Foundation·1988
    Same author

    Sex hormones modulate the response of pulmonary perivascular inflammation to cyclophosphamide therapy in MRL/MpJ-lpr/lpr mice.

    The American journal of pathology·1988
    Same journal

    Elevated CK-MB With Normal Total Creatine Kinase Levels in Patients Undergoing Maintenance Hemodialysis-Reply.

    Archives of internal medicine·2017
    Same journal

    Occult Carbon Monoxide Poisoning-Reply.

    Archives of internal medicine·2017
    Same journal

    Acquired Immune Deficiency Syndrome-Reply.

    Archives of internal medicine·2017
    Same journal

    Heparin Side Effects-Reply.

    Archives of internal medicine·2017
    Same journal

    Humanizing primary care medicine begins with stress.

    Archives of internal medicine·2017
    Same journal

    Legend omitted and number misrepresented.

    Archives of internal medicine·2013
    See all related articles

    Nortriptyline hydrochloride, used for depression, can cause severe hyperventilation and respiratory alkalosis in patients with end-stage renal disease. This case required mechanical ventilation, highlighting a previously unrecognized adverse effect of this medication.

    Area of Science:

    • Pharmacology
    • Nephrology
    • Critical Care Medicine

    Background:

    • Antidepressant medications like nortriptyline are commonly prescribed for depression.
    • End-stage renal disease (ESRD) can alter drug metabolism and increase susceptibility to adverse effects.
    • Respiratory alkalosis is a condition characterized by abnormally low carbon dioxide levels in the blood.

    Observation:

    • A 61-year-old male patient with ESRD experienced severe hyperventilation after initiating nortriptyline hydrochloride for depression.
    • The patient's condition necessitated mechanical ventilation and paralysis to manage the respiratory alkalosis.

    Findings:

    • This case presents a novel association between nortriptyline hydrochloride use and the development of severe hyperventilation.
    • The patient's underlying ESRD may have contributed to the unusual and severe adverse reaction.

    Related Experiment Videos

    Implications:

    • Clinicians should be aware of the potential for nortriptyline hydrochloride to induce hyperventilation, particularly in patients with renal impairment.
    • Further research is warranted to elucidate the mechanisms underlying this adverse effect and to identify risk factors.
    • This finding may necessitate revised prescribing guidelines or closer monitoring for patients with ESRD on nortriptyline therapy.