Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

130
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
130
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

132
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
132
Narcolepsy01:07

Narcolepsy

89
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
89
Blind Procedures02:07

Blind Procedures

10.6K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.6K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elicited Repetitive Daily Blindness Associated With Gain-of-Function <i>SCN1A</i> Variants and Responsiveness to Sodium Channel Blockers.

Neurology. Genetics·2026
Same author

Longitudinal Analysis of Sleep-Disordered Breathing and Cognitive Outcomes in Children Living With Sickle Cell Anaemia.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2026
Same author

Cerebral Blood Flow Decline in Adults With Sickle Cell Anemia: What Does It Mean and Is Treatment Required?

Neurology·2025
Same author

Airborne injustice: a preliminary exploration of the associations between pollutants and hospitalizations, sleep, and cognition in children and young adults living with sickle cell disease.

Journal of pediatric psychology·2025
Same author

Prevention of stroke in sickle cell disease.

Blood·2024
Same author

Decline in Processing Speed Tells Only Half the Story: Developmental Delay in Children Living with Sickle Cell Disease.

Children (Basel, Switzerland)·2024

Related Experiment Video

Updated: May 31, 2025

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.7K

Sleep Behaviour in Sickle Cell Disease: A Systematic Review and Meta-Analysis.

Melanie Koelbel1, Fenella J Kirkham1

  • 1Developmental Neurosciences Unit, Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.

Children (Basel, Switzerland)
|January 25, 2025
PubMed
Summary

Sleep behavior disorders are common in sickle cell disease (SCD). This review found inconsistent sleep patterns and durations, highlighting the need for standardized sleep assessment methods in pediatric SCD cohorts.

Keywords:
actigraphymeta-analysispolysomnographysickle cell diseasesleep behaviour disorderssleep diarysleep onset latencysystematic reviewtotal sleep time

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.7K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

599

Related Experiment Videos

Last Updated: May 31, 2025

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.7K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.7K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

599

Area of Science:

  • Hematology
  • Sleep Medicine
  • Pediatrics

Background:

  • Sickle cell disease (SCD) is frequently associated with sleep behavior disorders and sleep disordered breathing (SDB).
  • Previous systematic reviews have focused on SDB, necessitating a review specifically on sleep behavior in SCD.
  • Understanding sleep behavior is crucial for managing overall health in individuals with SCD.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis on sleep behavior in individuals with sickle cell disease.
  • To synthesize current research on sleep patterns, including total sleep time (TST) and sleep onset latency (SOL), in pediatric SCD cohorts.
  • To identify gaps and limitations in the existing literature regarding sleep assessment in SCD.

Main Methods:

  • A comprehensive literature search adhering to PRISMA guidelines was performed, including all languages and publication types up to February 2022.
  • Thirty-one studies utilizing polysomnography, actigraphy, and questionnaires/diaries in pediatric SCD populations were identified.
  • Meta-analyses were conducted where data permitted, with comparisons made between SCD patients and healthy controls.

Main Results:

  • Total sleep time (TST) decreased and sleep onset latency (SOL) increased with age in pediatric SCD cohorts.
  • Discrepancies in TST and SOL were observed across different measurement methods (self-report vs. objective measures), potentially due to parental overestimation.
  • Meta-analyses were limited by publication bias and heterogeneity, with no significant differences found in TST or SOL between SCD patients and controls in limited comparisons.

Conclusions:

  • Significant heterogeneity in findings, largely attributed to variations in sleep assessment methodologies, complicates the interpretation of sleep behavior in SCD.
  • A scarcity of robust case-control studies limits definitive conclusions.
  • Further research employing standardized and objective sleep assessment tools is needed to address existing literature gaps.