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Updated: May 31, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Neonatal Sepsis: A Comprehensive Review.

Charikleia Kariniotaki¹, Christina Thomou¹, Despoina Gkentzi²

¹Department of Neonatology/Neonatal Intensive Care Unit, School of Medicine, University of Crete, University Hospital of Heraklion, 71003 Heraklion, Greece.

Antibiotics (Basel, Switzerland)

|January 25, 2025

Summary

Neonatal sepsis is a major global health issue. This review covers current diagnostic tools, risk assessment, and prevention strategies for neonatal sepsis, addressing challenges in timely and accurate diagnosis.

Keywords:

early-onset sepsis late-onset sepsis sepsis biomarkers sepsis risk assessment tools

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Last Updated: May 31, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

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Published on: August 12, 2020

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

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A Data-Driven Approach to Quantifying Immune States in Sepsis

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Area of Science:

Neonatology
Infectious Diseases
Pediatric Critical Care

Background:

Neonatal sepsis is a leading cause of infant illness and death worldwide.
Current diagnostic criteria for neonatal sepsis lack consensus, complicating accurate identification.
Challenges include distinguishing culture-negative sepsis and the risks of both under- and over-treatment with antibiotics.

Purpose of the Study:

To review recent advancements in the diagnosis and management of neonatal sepsis.
To evaluate the effectiveness of sepsis risk assessment tools in term and preterm infants.
To summarize current and emerging diagnostic and preventive strategies for neonatal sepsis.

Main Methods:

Literature review of recent data on neonatal sepsis.
Analysis of the utility of sepsis risk assessment tools.
Evaluation of current diagnostic and preventive modalities.

Main Results:

No clear consensus definition for neonatal sepsis exists, impacting diagnosis.
Risk assessment tools, biomarkers, and new diagnostic techniques are under development and evaluation.
Timely diagnosis and appropriate antibiotic therapy are critical to prevent adverse outcomes.

Conclusions:

Accurate and timely diagnosis of neonatal sepsis remains a significant challenge.
A multifaceted approach involving risk assessment, biomarkers, and advanced diagnostics is needed.
Improved diagnostic and preventive strategies are crucial for reducing neonatal morbidity and mortality from sepsis.