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Updated: May 31, 2025
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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
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Thromboelastometry-Based Profiling of Haemostatic Alterations in Neonatal Sepsis by Causative Pathogens
Rozeta Sokou1,2, Eleni A Gounari3, Konstantina A Tsante4
1Neonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, 18454 Piraeus, Greece.
Antibiotics (Basel, Switzerland)
|January 25, 2025
Summary
Neonatal sepsis impacts blood clotting differently based on bacterial type. Gram-positive infections cause hypercoagulability, while Gram-negative infections lead to hypocoagulability and bleeding risks.
Area of Science:
- Neonatal intensive care
- Hematology
- Infectious diseases
Background:
- Neonatal sepsis is a critical condition with high mortality, particularly in premature infants.
- Understanding the impact of bacterial type on hemostasis in sepsis is crucial for treatment.
Purpose of the Study:
- To investigate if the hemostatic profile in neonatal sepsis differs between Gram-positive and Gram-negative bacterial infections.
- To utilize Rotational Thromboelastometry (ROTEM) for assessing these differences.
Main Methods:
- A prospective cohort study involving 128 neonates with sepsis in a Neonatal Intensive Care Unit (NICU).
- Comparison of ROTEM parameters between neonates with Gram-positive (33 cases) and Gram-negative (95 cases) infections.
- Analysis included EXTEM, INTEM assays, and multivariant analysis of clotting parameters.
Main Results:
- Significant differences in ROTEM parameters were observed between Gram-positive and Gram-negative sepsis.
- Gram-positive infections were associated with increased clotting potential (higher A10, α-angle, MCF).
- Gram-negative infections showed a more hypocoagulable profile, linked to higher hemorrhagic episode incidence.
Conclusions:
- Neonatal sepsis from Gram-positive bacteria induces a hypercoagulable state.
- Sepsis from Gram-negative bacteria results in a hypocoagulable state and increased bleeding risk.
- Findings support individualized treatment strategies for sepsis-related hemostatic disorders based on causative organism.
