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Endometrial Receptivity-Lessons from "Omics"
Louie Ye1,2, Evdokia Dimitriadis2
1Reproductive Service Unit, The Royal Women's Hospital, Melbourne, VIC 3052, Australia.
Abstract:
The window of implantation (WOI) is a critical phase of the menstrual cycle during which the endometrial lining becomes receptive and facilitates embryo implantation. Drawing on findings from various branches of "omics", including genomics, epigenomics, transcriptomics, proteomics, lipidomics, metabolomics, and microbiomics, this narrative review aims to (1) discuss mechanistic insights on endometrial receptivity and its implication in infertility; (2) highlight advances in investigations for endometrial receptivity; and (3) discuss novel diagnostic and therapeutic strategies that may improve reproductive outcomes.
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