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Correction: Kang et al. Fluid Flow to Electricity: Capturing Flow-Induced Vibrations with Micro-Electromechanical-System-Based Piezoelectric Energy Harvester. <i>Micromachines</i> 2024, <i>15</i>, 581.

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Updated: May 31, 2025

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
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Biocompatible Heterogeneous Packaging and Laser-Assisted Fluid Interface Control for In Situ Sensor in

Yu-Hsuan Lin1, Shing-Fung Lau2, Yen-Pei Lu1

  • 1Taiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu 300092, Taiwan.

Micromachines
|January 25, 2025
PubMed
Summary
This summary is machine-generated.

Advancements in biocompatible packaging and laser surface modification enable sophisticated in situ sensing for organ-on-a-chip systems. This technology is crucial for developing dynamic closed-loop cultures and future "organ twin" applications.

Keywords:
biocompatible heterogeneous packaginglaser surface modificationorgan twinorgan-on-a-chip (OoC)wettability

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Area of Science:

  • Biocompatible materials science
  • Microfluidics and biochip technology
  • Advanced sensor integration

Background:

  • Organ-on-a-chip development requires integrated in situ sensors and robust biochip packaging.
  • Achieving long-term dynamic closed-loop culture systems necessitates precise sensing and microfluidic control.
  • Existing packaging methods often impact fluid dynamics and biocompatibility.

Purpose of the Study:

  • To develop biocompatible heterogeneous packaging and laser surface modification techniques for biochips.
  • To enable encapsulation of electronic components with minimal disruption to fluid dynamics.
  • To create non-toxic packaging and fluid interface control for organ-on-a-chip systems, using a kidney-on-a-chip as a model.

Main Methods:

  • Encapsulation of miniature pressure sensors and control circuits using parylene-C, a biocompatible polymer.
  • Utilizing ultraviolet laser processing for surface modification of parylene-C.
  • Characterizing material wettability, morphology, and cytotoxicity using contact angle measurements and MTT assays.

Main Results:

  • Successful encapsulation of electronic components, isolating biochemical fluids from sensitive electronics.
  • Demonstrated tunable wettability of parylene-C (60°-110° contact angle) via precise laser processing.
  • Confirmed non-cytotoxicity of the materials and processing methods, ensuring biological compatibility.

Conclusions:

  • The developed packaging and laser modification techniques provide a viable solution for in situ sensing and advanced biochip packaging.
  • This technology supports the integration of electronic components in microfluidic devices without compromising fluid dynamics or biocompatibility.
  • The innovations are a significant step towards realizing functional