Using the Cardiac-Electrophysiological Balance Index to Predict Arrhythmia Risk After Colonoscopy.

Area of Science:

• Cardiology
• Gastroenterology
• Medical Diagnostics

Background:

• Colorectal cancer is a leading cause of cancer deaths in the U.S.
• Colonoscopy is vital for colorectal cancer screening and diagnosis.
• Bowel preparation and colonoscopy may induce electrolyte disturbances and autonomic dysfunction, potentially leading to cardiac arrhythmias.

Purpose of the Study:

• To evaluate the index of cardiac-electrophysiological balance (iCEB) as a predictor of ventricular arrhythmia risk associated with colonoscopy.
• To assess changes in iCEB following colonoscopy procedures.

Main Methods:

• Inclusion of patients with normal sinus rhythm undergoing elective colonoscopy.
• Acquisition of electrocardiography (ECG) recordings before bowel preparation and after the colonoscopy procedure.
• Comparison of pre- and post-procedure iCEB values.

Main Results:

• A statistically significant increase in QT interval duration was observed post-colonoscopy (370.9 ± 27.8 ms to 398.7 ± 29.4 ms, p < 0.001).
• The index of cardiac-electrophysiological balance (iCEB) significantly increased post-procedure (4.1 ± 0.5 to 4.5 ± 0.6, p < 0.001).
• Post-procedural heart rates were lower than pre-procedural heart rates (68.5 [53-108] bpm vs. 74.5 [60-108] bpm, p = 0.021).

Conclusions:

• Colonoscopy procedures are associated with a significant post-procedural increase in iCEB, indicating elevated ventricular arrhythmia risk.
• Routine iCEB assessment after colonoscopy can aid in identifying patients who may require closer cardiac monitoring.
• This assessment may help in managing potential cardiac complications following colonoscopy.