Related Experiment Video
Updated: May 7, 2026
08:40
Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
20.0K
Diabetes Mellitus as a Risk Factor for Complicated Urinary Tract Infections in Kidney Transplant Recipients
Severins Krohmals1, Christophe de Terwangne2,3, Arnaud Devresse1,3,4
1Department of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium.
Journal of Clinical Medicine
|January 25, 2025
Summary
Pre-transplant diabetes significantly increases the risk of urinary tract infections (UTIs) after kidney transplantation. Post-transplant diabetes mellitus also elevates UTI risk in these patients.
Area of Science:
- Nephrology
- Transplantation Immunology
- Infectious Diseases
Background:
- Urinary tract infections (UTIs) are a frequent complication following kidney transplantation.
- Diabetes mellitus, both pre-existing and post-transplant, may influence UTI development in kidney transplant recipients.
Purpose of the Study:
- To assess the impact of pre-existing diabetes mellitus and post-transplant diabetes mellitus (PTDM) on the incidence of pyelonephritis in kidney transplant recipients.
- To identify risk factors associated with UTIs in kidney transplant recipients.
Main Methods:
- Retrospective analysis of 299 adult kidney transplant recipients from 2018-2022.
- Patients classified into three groups: pre-transplantation diabetics, PTDM, and non-diabetics.
- Exclusion of asymptomatic bacteriuria and lower UTIs.
Main Results:
- A total of 100 UTIs occurred during a median follow-up of 31 months.
- Cumulative UTI incidence at 48 months was 34.9% (no diabetes), 56% (pre-transplant diabetes), and 47.3% (PTDM).
- Pre-transplant diabetes independently associated with a 79% increased UTI risk (aHR=1.79); female gender increased risk by 85%.
Conclusions:
- Pre-transplant diabetes mellitus is a significant risk factor for developing UTIs post-kidney transplantation.
- PTDM also contributes to increased UTI risk, though pre-transplant diabetes shows a stronger independent association.
Related Concept Videos
01:26Urinary Tract Infection I: Introduction
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
01:25Urinary Tract Infection II: Pathophysiology
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:28Diabetic Nephropathy
Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...