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Single-Capillary Dual Point-of-Care Testing to Support Cardio-Renal Diagnostic Decision-Making in Ambulatory Care
Perrin Ngougni Pokem1, Ali Khatib2, Florian Belik1
1Department of Clinical Biochemistry, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium.
Annals of Clinical and Laboratory Science
|July 23, 2026
Summary
A new point-of-care test (POCT) using a single fingerstick provides rapid creatinine/eGFR and NT-proBNP results. This dual biomarker approach supports timely clinical decisions in ambulatory cardio-renal care.
Area of Science:
- Cardiology
- Nephrology
- Point-of-Care Testing
Background:
- Integrated cardio-renal assessment is crucial for ambulatory care.
- Current methods may not support real-time decision-making during consultations.
Purpose of the Study:
- To evaluate a single-capillary dual point-of-care testing (POCT) strategy for creatinine/eGFR and NT-proBNP.
- To assess its utility for integrated clinical decision-making in a single visit.
Main Methods:
- Exploratory, single-center, real-world feasibility study.
- Single-fingerstick dual-POCT workflow for creatinine/eGFR and NT-proBNP.
- Analytical agreement assessed by Passing-Bablok and Bland-Altman; diagnostic agreement by Cohen's kappa at clinical thresholds.
Main Results:
- Good analytical agreement for both biomarkers.
- Substantial diagnostic agreement for eGFR (κ=0.71) and perfect agreement for NT-proBNP (κ=1.00).
- Dual biomarker results available within ~15 minutes, enabling same-visit decisions.
Conclusions:
- A single-capillary dual-biomarker POCT workflow facilitates rapid cardio-renal assessment in ambulatory settings.
- Simultaneous availability of complementary biomarkers enhances integrated, threshold-based clinical interpretation.
- This POCT strategy supports real-time clinical decision-making during a single patient visit.
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