TAS1R2 rs35874116 Associations with Taste, Diet, and Health in an Italian Population

The TAS1R2 SNP rs35874116 has previously been associated with sweet taste, diet, and health status, although never comprehensively in a single study. Also, associations between TAS1R2 and sweet taste might be body mass index (BMI)-dependent. Therefore, this study aimed to conduct a comprehensive investigation of rs35874116 and sweet taste intensity and liking, food liking, and diet and health status whilst considering BMI.

Five-hundred and fifty-four participants were recruited. Linear regression models were used to explore rs35874116 associations with sweet taste intensity and liking, food liking, and diet and health status. A secondary analysis stratified participants by BMI <25/≥25 kg/m².

The rs35874116 wildtype was associated with increased sweet taste intensity (p = 0.0345, B 1.29, SE 0.61) and liking (p = 0.021, B 0.25, SE 0.11). However, these associations only remained in BMI ≥25 individuals (intensity: p = 0.037, B 1.29, SE 0.61, liking: p = 0.008, B 0.46, SE 0.17). It was also associated with decreased diet quality (p = 0.03, B -0.27, SE 0.13) and reduced free sugar consumption but increased saturated fat consumption in BMI ≥25 individuals (free sugars: p = 0.0416, B -0.8, SE 0.38, saturated fat: p = 0.031, B 1.38, SE 0.62). There was no association with the mean liking score for sweet foods, although there were some associations with individual foods, which require further investigation. There were no associations with health status.

This study revealed an association between the rs35874116 wildtype and an increased intensity and liking of the sweet taste and a corresponding worse overall dietary quality. This study adds to previous evidence regarding how associations between TAS1R2 and sweet taste are BMI-dependent.