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Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute

Yasmim Gabrielly Souza Sousa1, Carolina Alcântara Maneschy1, Carolina Costa Monteiro2

  • 1Postgraduate Program in Virology, Teaching and Scientific Information Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, Brazil.

Viruses
|January 25, 2025
PubMed

Insights

Human bocavirus (HBoV) was detected in 9.2% of acute gastroenteritis cases in Northern Brazil. Multiple HBoV genotypes and co-infections with other viruses were observed, highlighting the need for ongoing surveillance.

Area of Science:

  • Virology
  • Pediatrics
  • Epidemiology

Background:

  • Acute gastroenteritis (AG) is a significant pediatric health concern.
  • Emerging evidence suggests a link between human bocavirus (HBoV) and AG.
  • HBoV is a non-enveloped, single-stranded DNA virus within the Parvoviridae family.

Purpose of the Study:

  • To determine the prevalence of HBoV in pediatric AG cases in Northern Brazil.
  • To identify HBoV genotypes circulating in the region.
  • To investigate co-infection patterns involving HBoV.

Main Methods:

  • Analysis of fecal samples from patients with AG collected between 2017 and 2022.
  • Detection of HBoV using PCR and nested-PCR.
  • Nucleotide sequencing for HBoV genotype identification.

Main Results:

  • HBoV was detected in 9.2% (64/692) of the analyzed samples.
  • Detected genotypes included HBoV-1 (42.5%), HBoV-2 (22.5%), HBoV-3 (32.5%), and HBoV-4 (2.5%).
  • HBoV co-infection occurred in 48.3% of cases, most frequently with rotavirus A (RVA).

Conclusions:

  • HBoV is a relevant pathogen in pediatric acute gastroenteritis in Northern Brazil.
  • The genetic diversity of HBoV and frequent co-infections warrant further investigation.
  • Continuous surveillance is crucial for understanding HBoV epidemiology, seasonality, and clinical impact.

Keywords:
acute gastroenteritisgenotypeshuman bocavirusviral coinfection

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