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Updated: May 30, 2025
A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Risk of clinically significant prostate cancer undercategorized by multiparametric magnetic resonance imaging
Wangshu Zhu1, Haining Long1, Weibin Yu1
1Department of Diagnostic and Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background:
To investigative potential clinicopathological characteristics and imaging-related risk factors of clinically significant prostate cancer (csPCa) undercategorized in patients with negative or equivocal MRI.
Methods:
This retrospective study included 581 patients with pathologically confirmed csPCa (Gleason score ≥ 3 + 4), including 108 undercategorized csPCa and 473 detected csPCa. All patients underwent multiparametric MRI (mpMRI). The undercategorized csPCa was defined as a MRI result with PI-RADS ≤ 3. The clinicopathological characteristics and imaging-related factors were compared between the undercategorized group(Group A) (PI-RADS 1-3) and detected group (Group B) (PI-RADS 4-5).
Results:
The age, total PSA levels, PSAD, free PSA, prostate imaging quality (PI-QUAL) scores, and Gleason scores were significantly lower in the Group A than Group B. The lesions were larger and involved in peripheral and transition zones in the Group B. A significant difference in the second reading opinion. Age (odds ratio [OR], 0.94), PSAD (OR, 0.09), and PI-QUAL scores (OR, 0.25) were significantly associated with the undercategorized csPCa. The rate of undercategorized csPCa with these three risk factors (age, PSAD, and PI-QUAL scores of < 71, < 0.355, and < 3, respectively) was 68.62%. The lack of zoomed-DWI resulted in lower PI-QUAL scores. Finally, the probability of undercategorized csPCa without zoomed DWI was 3.186 times higher than that with zoomed DWI when the PSAD ratio is lower than 0.355.
Conclusions:
Low image quality, younger age, and lower PSAD contribute to csPCa undercategorized by mpMRI. Moreover, the use of zoomed DWI decreased undercategorized csPCa by improving PI-QUAL scores of MRI images.
