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Related Experiment Video

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Engineering a Bilayered Hydrogel to Control ASC Differentiation
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Mechanically robust, mouldable, dynamically crosslinked hydrogel flap with multiple functionalities for accelerated

Hitasha Vithalani1, Harshil Dave1, Hemant Singh1

  • 1Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gujarat, India.

Biomaterials Advances
|January 25, 2025
PubMed
Summary

A new biodegradable hydrogel flap, incorporating tannic acid and vancomycin, effectively treats deep skin wounds. This advanced wound dressing offers antioxidant and antibacterial properties, promoting faster healing and tissue regeneration.

Keywords:
GelatinMultifunctionalPolymeric hydrogelsStretchableWound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Deep cutaneous wounds pose significant clinical challenges due to factors like oxidative stress, infection, and extracellular matrix degradation.
  • Existing therapies often fail to address the multifaceted nature of complex wound healing.
  • There is a critical need for advanced, multifunctional wound dressings to enhance healing outcomes.

Purpose of the Study:

  • To engineer a novel multifunctional hydrogel flap for promoting the healing of deep skin wounds.
  • To incorporate antioxidant and antibacterial agents into a biodegradable hydrogel matrix.
  • To evaluate the physical, chemical, and biological properties of the developed hydrogel for wound care applications.

Main Methods:

  • Fabrication of a biodegradable hydrogel flap using gelatin (G) and poly-methyl vinyl ether-alt-maleic acid (MA).
  • Incorporation of tannic acid (TA) for antioxidant properties and vancomycin (V) for antibacterial activity.
  • Chemical crosslinking using EDC (E) and NHS (N) to form the G-MA-TA-V/E-N hydrogel flap with a honeycomb microstructure.

Main Results:

  • The hydrogel flap exhibited desirable properties including stretchability, mouldability, adhesion to wet surfaces, and a porous microstructure.
  • In vitro studies confirmed significant antioxidant, antibacterial, and absorption capabilities.
  • In vivo assessments demonstrated accelerated wound contraction, enhanced re-epithelialization, angiogenesis, and apocrine gland formation.

Conclusions:

  • The developed gelatin-poly-methyl vinyl ether-alt-maleic acid-tannic acid-vancomycin hydrogel flap is a promising multifunctional therapeutic option for deep skin wounds.
  • Its unique properties and demonstrated efficacy in promoting accelerated healing underscore its potential as a cost-effective wound care solution.
  • Integration with medical devices for tissue adhesion could further enhance its clinical applicability.