Related Experiment Video

Updated: May 30, 2025

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
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Atrial fibrillation versus atrial myopathy in thrombogenesis: Two sides of the same coin?

Panteleimon E Papakonstantinou1, José Miguel Rivera-Caravaca2, Mauro Chiarito3

  • 1Atrial Fibrillation Institute, Heart and Vascular Centre, Mater Private Hospital, 71 Eccles St, Dublin 7, D07 WKW8, Dublin 7, Dublin, Ireland; Cardiovascular Research Institute Dublin, Royal College of Surgeons of Ireland, Mater Private Hospital, 71 Eccles St, Dublin 7, D07 WKW8, Dublin 7, Dublin, Ireland.

Trends in Cardiovascular Medicine
|January 25, 2025
PubMed

Insights

Atrial fibrillation (AF) and atrial myopathy both increase stroke risk by promoting clot formation. Understanding their combined impact is key for better thrombogenesis management in high-risk patients.

Area of Science:

  • Cardiology
  • Thrombosis Research
  • Vascular Medicine

Background:

  • Atrial fibrillation (AF) and atrial myopathy are linked to cardiovascular disease and stroke.
  • AF increases thrombogenesis via irregular heart rhythms and blood stasis.
  • Atrial myopathy contributes to thromboembolic events independently of AF.

Purpose of the Study:

  • To review the relationship between AF and atrial myopathy in thrombogenesis.
  • To discuss epidemiology, risk factors, and clinical implications.
  • To explore advancements in antithrombotic therapy and risk assessment.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of AF burden and stroke risk association.
  • Evaluation of atrial myopathy's role in thromboembolism pathogenesis.

Main Results:

  • Both AF and atrial myopathy are significant contributors to stroke risk.
  • CHA2DS2-VASc score assesses patient risk profiles.
  • Current guidelines for anticoagulant therapy are evaluated.

Conclusions:

  • A holistic approach to thrombogenesis risk assessment is needed.
  • Atrial myopathy is a critical factor in stroke risk, beyond AF alone.
  • Future research should focus on novel antithrombotic and anti-inflammatory strategies.

Keywords:
AnticoagulationAtrial fibrillationAtrial myopathyStrokeThrombosis

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