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Updated: May 30, 2025

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Generating Genetically Modified Plasmodium berghei Sporozoites
Published on: May 5, 2023
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Genetically attenuated parasites show promise as a next-generation malaria vaccine
Julius C R Hafalla1, Steffen Borrmann2, Kai Matuschewski3
1London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Trends in Parasitology
|January 25, 2025
Abstract:
Metabolically active, genetically attenuated Plasmodium falciparum parasite lines are promising second-generation malaria vaccine candidates. Lamers et al. and Roozen et al. demonstrated in recent Phase 1/2a trials that GA2 parasites, designed to arrest late during liver-stage development and transmitted via mosquito bites, can induce substantial protection against sporozoite challenge infection.

