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Related Concept Videos

Fibril-associated Collagen01:11

Fibril-associated Collagen

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
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Type IV Collagen of Basal Lamina01:05

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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
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Collagens are the Major Structural Proteins of ECM01:13

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Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
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The Bone Matrix01:18

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Extracellular Matrix01:26

Extracellular Matrix

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Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
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Updated: May 30, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

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Collagen-mediated cardiovascular calcification.

Junlin Chen1, Chunyang Ma1, Jinyu Li2

  • 1Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

International Journal of Biological Macromolecules
|January 26, 2025
PubMed
Summary
This summary is machine-generated.

Cardiovascular calcification involves collagen acting as a scaffold and signaling pathway. Understanding collagen

Keywords:
AtherosclerosisCalcific aortic valve diseaseCalcificationCollagen

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Area of Science:

  • Cardiovascular Biology
  • Biochemistry
  • Pathology

Background:

  • Cardiovascular calcification, including vascular and valvular types, is prevalent in the elderly.
  • Collagen is crucial for cardiovascular calcification, influencing mineral deposition and cellular processes.
  • The balance between collagen synthesis and degradation is vital; dysregulation contributes to pathological outcomes.

Purpose of the Study:

  • To review collagen subtypes in the cardiovascular system under physiological and pathological conditions.
  • To elucidate the role of collagen in the formation and progression of cardiovascular calcification.
  • To explore strategies for modulating collagen in cardiovascular calcification.

Main Methods:

  • Literature review of collagen's role in cardiovascular calcification.
  • Analysis of collagen subtypes, distribution, and pathological changes.
  • Description of cardiovascular calcification processes and stages.

Main Results:

  • Collagen acts as a scaffold for mineral deposition and mediates calcification via signal transduction.
  • It guides matrix vesicle aggregation and influences cell behavior in calcification lesions.
  • Pathological changes in collagen are integral to the development of cardiovascular calcification.

Conclusions:

  • Collagen is a key mediator in cardiovascular calcification, affecting both structure and cellular signaling.
  • Targeting collagen pathways presents potential therapeutic strategies for cardiovascular calcification.
  • Further research into collagen's dynamic role is warranted for developing effective interventions.