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Rapid Generation of Amyloid from Native Proteins In vitro
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Pathogenesis-Associated Bacterial Amyloids: The Network of Interactions.

Haidar Fayoud1,2, Mikhail V Belousov1,2, Kirill S Antonets1,2

  • 1Faculty of Biology, St. Petersburg State University, St. Petersburg, 199034, Russia.

Biochemistry. Biokhimiia
|January 26, 2025
PubMed
Summary

Bacterial amyloids contribute to disease pathogenesis and biofilm formation. These microbial amyloids, alongside host and dietary amyloids, form a complex network influencing human health and disease.

Keywords:
amyloidamyloid networkbacteriabeta-sheetcross-seedingfibrilholobionthumaninfectionpathogenesisprotein aggregatevirulence

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Area of Science:

  • Microbiology
  • Biochemistry
  • Immunology

Background:

  • Amyloids are protein aggregates with a cross-β structure, known for resistance and involvement in pathogenesis and function.
  • Bacteria exhibit diverse functional amyloids, primarily linked to virulence, biofilm formation, and host colonization.
  • Emerging research highlights amyloids' role in spatial proteome regulation and their presence within the human holobiont.

Purpose of the Study:

  • To review bacterial amyloids involved in human disease pathogenesis.
  • To discuss the significance of bacterial amyloids within the holobiont-associated amyloid network.
  • To explore the complex interactions between bacterial, host, and external amyloids.

Main Methods:

  • Literature review of studies on bacterial amyloids and their roles in disease.
  • Analysis of the functional and pathological implications of bacterial amyloids.
  • Discussion of the interplay within the three-component holobiont amyloid network.

Main Results:

  • Bacterial amyloids are crucial for virulence, aiding in biofilm formation and host adaptation.
  • Amyloids can modulate the aggregation of other proteins, influencing proteome organization.
  • The human holobiont comprises amyloids from host, microbiome, and external sources, creating a complex network.

Conclusions:

  • Bacterial amyloids play a significant role in human disease pathogenesis.
  • The interaction of bacterial, host, and dietary amyloids adds complexity to understanding amyloid-related diseases.
  • Further research into microbiome-produced amyloids is essential for understanding holobiont health.