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Published on: December 5, 2020
Chemical Constituents of the Deep-Sea-Derived Fungus Trichoderma simmonsii ZEN3
Yun-Fei Song1, Yuan Wang2, Zheng-Biao Zou2,3
1Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, China.
Abstract:
Two new nor-rubrofusarin derivatives (trichsimins A and B, 1 and 2) and one new chromone derivative (trichsimin C, 5) were isolated from the deep-sea-derived Trichoderma simmonsii ZEN3 along with 20 known compounds (3, 4, and 6-23). The structures of the new compounds were established by detailed analyses of the NMR, HRESIMS, and optical rotatory dispersion (ORD) data. Nafuredin (14) exhibited potent inhibition against RSL3-induced ferroptosis with an EC50 value of 5.54 µM.
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